Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents
Authors
Zhang, Xing
Khalidi, Omar
Kim, So Young
Wang, Ruitong
Schultz, Victor
Cress, Brady F.
Gross, Richard A.
Koffas, Mattheos A.G.
Linhardt, Robert J.
Issue Date
2016-07-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
A series of 5,7-dihydroxyflavanone derivatives were efficiently synthesized. Their antimicrobial efficacy on Gram-negative, Gram-positive bacteria and yeast were evaluated. Among these compounds, most of the halogenated derivatives exhibited the best antimicrobial activity against Gram-positive bacteria, the yeast Saccharomyces cerevisiae, and the Gram-negative bacterium Vibrio cholerae. The cytotoxicities of these compounds were low as evaluated on HepG2 cells using a cell viability assay. This study suggests that halogenated flavanones might represent promising pharmacological candidates for further drug development.
Description
Bioorganic & Medicinal Chemistry Letters, 26, 3089–3092
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents, X. Zhang, O. Khalidi, S.-Y. Kim, R. Wang, V. Schultz, B. F. Cress, R. A. Gross, M. A.G. Koffas, R. J. Linhardt, Bioorganic & Medicinal Chemistry Letters, 26, 3089–3092, 2016
Publisher
Elsevier
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
14643405
0960894X
0960894X