Chiral force generation of cells on micropatterns
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Authors
Certo, Anthony Miles
Issue Date
2015-05
Type
Electronic thesis
Thesis
Thesis
Language
ENG
Keywords
Biomedical engineering
Alternative Title
Abstract
Asymmetric tissue development is a well-conserved biological property that is imperative during embryogenesis. Failure to establish proper left-right (LR) asymmetry (also known as handedness and chirality) results in potentially deadly disease states; such as congenital heart defects. Understanding which genetic and epigenetic factors affect the establishment of left-right asymmetry creates opportunities to better diagnose and treat disease. Wan et al. has developed a high throughput system utilizing micropatterning and image analysis software to effectively measure cell chirality through migration and alignment in vitro. Although robust, biomechanical mechanisms are not yet well understood.
Description
May 2015
School of Engineering
School of Engineering
Full Citation
Publisher
Rensselaer Polytechnic Institute, Troy, NY