Conformational Analysis of Sucrose Octasulfate by High Resolution Nuclear Magnetic Resonance Spectroscopy
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Authors
Desai, Umesh R.
Vlahov, Ioncho R.
Pervin, Azra
Linhardt, Robert J.
Issue Date
1995-10-02
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
The aluminum salt of sucrose octasulfate (SOS) is a drug called Sucralfate (Carafate), which is widely used for the treatment of duodenal ulcers. Folkman et al. [1] have recently suggested that Sucralfate binds to fibroblast growth factor (FGF), protecting it from denaturation in the strongly acidic conditions present in the stomach. This hypothesis has generated considerable interest in sucrose octasulfate and its interaction with FGF. The sodium and potassium salts of SOS also bind FGF [2], but these differ from Sucralfate in being water soluble and are more easily studied.
Description
Carbohydrate Research, 275, 391-401
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Conformational Analysis of Sucrose Octasulfate by High Resolution Nuclear Magnetic Resonance Spectroscopy, U.R. Desai, I. R. Vlahov, A. Pervin, R. J. Linhardt, Carbohydrate Research, 275, 391-401, 1995.
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Volume
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PubMed ID
DOI
ISSN
86215