Conformational Analysis of Sucrose Octasulfate by High Resolution Nuclear Magnetic Resonance Spectroscopy

Desai, Umesh R.
Vlahov, Ioncho R.
Pervin, Azra
Linhardt, Robert J.
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Conformational Analysis of Sucrose Octasulfate by High Resolution Nuclear Magnetic Resonance Spectroscopy, U.R. Desai, I. R. Vlahov, A. Pervin, R. J. Linhardt, Carbohydrate Research, 275, 391-401, 1995.
The aluminum salt of sucrose octasulfate (SOS) is a drug called Sucralfate (Carafate), which is widely used for the treatment of duodenal ulcers. Folkman et al. [1] have recently suggested that Sucralfate binds to fibroblast growth factor (FGF), protecting it from denaturation in the strongly acidic conditions present in the stomach. This hypothesis has generated considerable interest in sucrose octasulfate and its interaction with FGF. The sodium and potassium salts of SOS also bind FGF [2], but these differ from Sucralfate in being water soluble and are more easily studied.
Carbohydrate Research, 275, 391-401
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The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
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Rensselaer Polytechnic Institute, Troy, NY
Carbohydrate Research