Biochemical strategies for enhancing the in vivo production of natural products with pharmaceutical potential
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Authors
Mora-Pale, Mauricio
Sanchez-Rodriguez, Sandra P.
Linhardt, Robert J.
Dordick, Jonathan S.
Koffas, Mattheos A.G.
Issue Date
2014-02-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Natural products have been associated with significant health benefits in preventing and treating various chronic human diseases such as cancer, cardiovascular diseases, diabetes, Alzheimer's disease, and pathogenic infections. However, the isolation, characterization and evaluation of natural products remain a challenge, mainly due to their limited bioavailability. Metabolic engineering and fermentation technology have emerged as alternative approaches for generating natural products under controlled conditions that can be optimized to maximize yields. Optimization of these processes includes the evaluation of factors such as host selection, product biosynthesis interaction with the cell's central metabolism, product degradation, and byproduct formation. This review summarizes the most recent biochemical strategies and advances in expanding and diversifying natural compounds as well as maximizing their production in microbial and plants cells.
Description
Current Opinion in Biotechnology, 25, 86–94
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Biochemical strategies for enhancing the in vivo production of natural products with pharmaceutical potential, M. Mora-Pale, S.P. Sanchez-Rodriguez, R. J. Linhardt, J. S. Dordick, M. Koffas, Current Opinion in Biotechnology, 25, 86–94, 2014.
Publisher
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
18790429
9581669
9581669