Heparin Contamination and Issues Related to Raw Materials and Controls

Authors
Zhu, Yuanyuan
Zhang, Fuming
Linhardt, Robert J.
Sasisekharan,
Lee, R.
Rosenberg, S.L.
Walker, A.
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
2019-01-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Heparin Contamination and Issues Related to Raw Materials and Controls, Y. Zhu, F. Zhang, R. J. Linhardt, In The Science and Regulations of Naturally Derived Complex Drugs, Sasisekharan, R., Lee, S.L., Rosenberg, A., Walker, L.A. (Eds.), AAPS Advances in the Pharmaceutical Sciences Series 39, Chapter 11, pp 191-206, Springer Nature, NY, 2019.
Abstract
Heparin is a century-old polypharmacological drug critical for the practice of modern medicine. In recent years, there have been a number of issues arising in the preparation of heparin from food animal tissues. The most severe problem was the adulteration of porcine intestinal heparin with a toxic semisynthetic look-alike polysaccharide, oversulfated chondroitin sulfate, which resulted in a number of patient deaths. Since this crisis, regulatory and analytical control of heparin has been markedly improved; new challenges in securing the heparin supply chain have prompted the reintroduction of heparins from new animal sources . In future, the introduction of bioengineered heparins might offer better approaches for securing this critical drug.
Description
AAPS Advances in the Pharmaceutical Sciences Series 39, Chapter 11, pp 191-206, Springer Nature, NY
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
AAPS Advances in the Pharmaceutical Sciences Series
https://harc.rpi.edu/
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