Design of homogeneous and reversible low molecular weight heparins
Authors
Xu, Y.
Cai, C.
Chandarajoti, K.
Hsieh, P.-H.
Li, L.
Pham, T.Q.
Sparkenbaugh, E.M.
Sheng, J.
Key, N.S.
Pawlinski, R.
Issue Date
2014
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Low-molecular-weight heparins (LMWHs) are carbohydrate-based anticoagulants clinically used to treat thrombotic disorders, but impurities, structural heterogeneity or functional irreversibility can limit treatment options. We report a series of synthetic LMWHs prepared by cost-effective chemoenzymatic methods. The high activity of one defined synthetic LMWH against human factor Xa (FXa) was reversible in vitro and in vivo using protamine, demonstrating that synthetically accessible constructs can have a critical role in the next generation of LMWHs.
Description
Nature Chemical Biology, 10, 248-250
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Design of homogeneous and reversible low molecular weight heparins, Y. Xu, C. Cai, K. Chandarajoti, P.-H. Hsieh, L.Li, T. Q. Pham, E. M. Sparkenbaugh, J. Sheng, N. S. Key, R. Pawlinski, E. N. Harris, R.J. Linhardt, Jian Liu, Nature Chemical Biology, 10, 248-250, 2014.
Publisher
Nature