New Potent Insecticidal Agent: 4’-Fucosyl Avermectin Derivative

Wei, Guohua
Du, Yuguo
Linhardt, Robert J.
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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New Potent Insecticidal Agent: 4’-Fucosyl Avermectin Derivative, G. Wei, Y. Du R.J. Linhardt, Tetrahedron Letters, 45, 6895-6898, 2004.
A 4′-fucosyl avermectin derivative was designed and synthesized. This new avermectin derivative showed excellent in vivo bioactivity against cabbage larvae when compared to commercially available avermectin B1a. In this synthesis, thioglycosyl donors, but not trichloroacetimidates, were found compatible with sugar-macrolide synthesis under rt promotion with NIS or I2 in N-methylpyrrolidone.
Tetrahedron Letters, 45, 6895-6898
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The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
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Rensselaer Polytechnic Institute, Troy, NY
Tetrahedron Letters