Site-selective reactions for the synthesis of glycoconjugates in polysaccharide vaccine development
No Thumbnail Available
Authors
Lin, Lei
Qiao, Meng
Zhang, Xing
Linhardt, Robert J.
Issue Date
2020-02-15
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Carbohydrates are often found linked to lipids or proteins, to form glycoconjugates such as glycolipids, glycoproteins and proteoglycans. These glycoconjugates play important biological roles, involving cell-cell recognition, inflammation, immune response, tumor metastasis and in viral/bacterial/parasitic infections. However, it is difficult to obtain these naturally occurring glycoconjugates as they are often heterogeneous compositions, which causes batch-to-batch variability of structure and activity often leading an incomplete understanding of their mechanism of action. Thus, the efficient preparation of synthetic glycoconjugates, possessing well-defined compositions and reproducible biological properties is highly desirable. In the present review, we summarize the advances in site-selective approaches for glycoconjugate synthesis and, in particular, the preparation of polysaccharide vaccines.
Description
Carbohydrate Polymers, 230, 115643
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Site-selective reactions for the synthesis of glycoconjugates in polysaccharide vaccine development, L. Lin, M. Qiao, X. Zhang, R. J. Linhardt, Carbohydrate Polymers, 230, 115643, 2020.
Publisher
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
1448617