Structural analysis of bovine derived heparins

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Authors
St.Ange, Kalib
Issue Date
2017-12
Type
Electronic thesis
Thesis
Language
ENG
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Chemistry
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Abstract
The harsh purification process used to prepare heparin leaves the heparin product largely unaffected except for its reducing end tetrasaccharide linkage region. GlyserineAc is present in porcine and bovine heparin but is absent in LMW heparin. We hypothesized that the peracetic acid bleaching adds an O-acetyl group that is selectively lost during β-elimination in the LMWH production process. The tetrasaccharide composition of bovine and porcine heparin is similar as are different batches from the same supplier. This emphasizes how similar processing results in similar heparin regardless of whether bovine or porcine is used.
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December 2017
School of Science
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Rensselaer Polytechnic Institute, Troy, NY
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