Solid-Phase Chemoenzymatic Synthesis of Neuraminic Acid Based C-glycosides
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Authors
Baytas, S.N.
Wang, Qun
Karst, N.A.
Linhardt, Robert J.
Issue Date
2004
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
The chemoenzymatic regioselective acylation of Neu5Ac followed by SmI2-mediated C-glycosylation on a solid support is described for five C-glycosides. This method should facilitate the construction of combinatorial libraries of inhibitors of neuraminidase activity and hemagglutinin interaction as potential antiviral agents.
Description
Journal of Organic Chemistry, 69, 6900-6903
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Solid-Phase Chemoenzymatic Synthesis of Neuraminic Acid Based C-glycosides, S.N. Baytas, Q. Wang, N.A. Karst, R.J. Linhardt, Journal of Organic Chemistry, 69, 6900-6903, 2004.
Publisher
American Chemical Society (ACS)