Solid-Phase Chemoenzymatic Synthesis of Neuraminic Acid Based C-glycosides

Baytas, S.N.
Wang, Qun
Karst, N.A.
Linhardt, Robert J.
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Solid-Phase Chemoenzymatic Synthesis of Neuraminic Acid Based C-glycosides, S.N. Baytas, Q. Wang, N.A. Karst, R.J. Linhardt, Journal of Organic Chemistry, 69, 6900-6903, 2004.
The chemoenzymatic regioselective acylation of Neu5Ac followed by SmI2-mediated C-glycosylation on a solid support is described for five C-glycosides. This method should facilitate the construction of combinatorial libraries of inhibitors of neuraminidase activity and hemagglutinin interaction as potential antiviral agents.
Journal of Organic Chemistry, 69, 6900-6903
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The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
American Chemical Society (ACS)
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Rensselaer Polytechnic Institute, Troy, NY
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