Solid-Phase Chemoenzymatic Synthesis of Neuraminic Acid Based C-glycosides

Authors
Baytas, S.N.
Wang, Qun
Karst, N.A.
Linhardt, Robert J.
ORCID
https://orcid.org/0000-0003-2219-5833
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Issue Date
2004
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Full Citation
Solid-Phase Chemoenzymatic Synthesis of Neuraminic Acid Based C-glycosides, S.N. Baytas, Q. Wang, N.A. Karst, R.J. Linhardt, Journal of Organic Chemistry, 69, 6900-6903, 2004.
Abstract
The chemoenzymatic regioselective acylation of Neu5Ac followed by SmI2-mediated C-glycosylation on a solid support is described for five C-glycosides. This method should facilitate the construction of combinatorial libraries of inhibitors of neuraminidase activity and hemagglutinin interaction as potential antiviral agents.
Description
Journal of Organic Chemistry, 69, 6900-6903
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
American Chemical Society (ACS)
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
https://harc.rpi.edu/
Access
A full text version is available in DSpace@RPI