Nano-based Neoproteoglycans – Blood Compatible Carbon Nanotubes

Murugesan, Saravanababu
Park, Tae Joon
Yang, Hoichang
Mousa, Shaker
Linhardt, Robert J.
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Nano-based Neoproteoglycans – Blood Compatible Carbon Nanotubes, S. Murugesan, T. Park, H. Yang, S. Mousa and R. J. Linhardt, Langmuir, 22,3461-3463, 2006.
Although nanotechnology has provided a rich variety of nanomaterials (1–100 nm) for in vivo medical applications, the blood compatibility of all these nanobiomaterials is still largely unexamined. Here, we report the preparation of blood-compatible carbon nanotubes (CNTs) that potentially represent the building blocks for nanodevices having in vivo applications. Activated partial thromboplastin time (APTT) and thromboelastography (TEG) studies prove that heparinization can significantly enhance the blood compatibility of nanomaterials.
Langmuir, 22,3461-3463
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The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
American Chemical Society (ACS)
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
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