Heparin as a Potential Therapeutic Agent to Reverse Vascular Remodeling
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Authors
Garg, H.
Thompson, B.T.
Linhardt, Robert J.
Hales, C.A.
Issue Date
2003
Type
Book chapter
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Vascular changes after chronic hypoxia are characterized by hyperplasia, hypertrophy, and migration of smooth muscle cells (SMCs) in the media of muscular and partially muscular pulmonary arteries (1,2). A number of factors are known to cause SMC migration, such as serum, platelet-derived growth factor (PDGF)- BB (3,4), transforming growth factor-β (5), fibrinogen (6), oxidized low-density lipoprotein (7,8), and angiotensin II (9,10).
Description
Proteoglycans and Lung Disease, H.G. Garg, P.J. Roughley, C.A. Hales (Eds.), Chapter 18, 377-398
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Heparin as a Potential Therapeutic Agent to Reverse Vascular Remodeling, H. Garg, B.T. Thompson, R.J. Linhardt, C.A. Hales, Proteoglycans and Lung Disease, H.G. Garg, P.J. Roughley, C.A. Hales (Eds.), Chapter 18, 377-398, 2003.