High-resolution and high sensitivity mesoscopic fluorescence tomography based on de-scanning EMCCD: system design and thick tissue imaging applications

Authors
Öztürk, Mehmet Saadeddin
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Other Contributors
Intes, Xavier
Dai, Guohao
Wang, Ge, 1957-
Boas, David A.
Chen, Yu
Issue Date
2016-12
Keywords
Biomedical engineering
Degree
PhD
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
Full Citation
Abstract
Mesoscopic Fluorescence Molecular Tomography (MFMT) is an emerging imaging modality that offers unique potential for the non-invasive molecular assessment of thick in-vitro and in-vivo live tissues. This novel imaging modality is based on an optical inverse problem that allows for retrieval of the quantitative spatial distribution of fluorescent tagged bio-markers at millimeter depth. MFMT is well-suited for in-vivo subsurface tissue imaging and thick bio-printed specimens due to its high sensitivity and fast acquisition times, as well as relatively large fields of view.
Description
December 2016
School of Engineering
Department
Dept. of Biomedical Engineering
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
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