Development of an atmospheric-pressure solution-cathode glow discharge as an ionization source for mass spectrometry

Authors
Walton, Courtney L.
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Other Contributors
Shelley, Jacob T., 1984-
McGown, Linda Baine
Rogers, Karyn
Linhardt, Robert J.
Issue Date
2019-12
Keywords
Chemistry
Degree
PhD
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
Full Citation
Abstract
The SCGD is a direct current, atmospheric-pressure glow discharge sustained in the open air between a metal anode and a flowing conductive solution, which serves as the cathode. Analytes of interest are introduced into the flowing solution where they are transported into the plasma and ionized before introduction to the mass spectrometer. Our research has found the SCGD is a unique ionization source in that it produces both protonated molecular ions from labile biomolecules and with source parameter changes can yield fragmentation of the same species within the source. The source has also been shown to be capable of producing gaseous ions from elemental species as well as small molecules. As such, a basic understanding of the ionization and fragmentation mechanisms, as well as the source parameters that lead to these conditions, is essential to optimize the system for a range of analytes.
Description
December 2019
School of Science
Department
Dept. of Chemistry and Chemical Biology
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
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