CS Lyases: Structure, Activity and Applications in Analysis and the Treatment of Diseases
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Authors
Linhardt, Robert J.
Avci, Fikri Y.
Toida, Toshihiko
Kim, Yeong Shik
Cygler, Miroslaw
Issue Date
2006-12-01
Type
Book chapter
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Glycosaminoglycans (GAGs) are a family of highly sulfated, complex mixture of linear polysaccharides that display a wide array of biological activities (Boneu, 1996; Jackson et al., 1991). GAGs can be classified into four basic types—hyaluronan, chondroitin/dermatan sulfates (CS/DS), heparin/heparan sulfate, and keratan sulfate (Capila and Linhardt, 2002; Esko and Selleck, 2002; Iozzo, 1998; Linhardt and Toida, 2004). Chondroitin/dermatan sulfates are the focus of this chapter. Chondroitin/dermatan sulfates are linear, polydisperse GAGs with a repeating core of disaccharide structure composed of a d-glucopyranosyl uronic (GlcAp) acid or L-idopyranosyl uronic (IdoAp) acid glycosidically linked to 2-deoxy, 2-acetamido-d-galactopyranose (GalpNAc) residue (Fig. 1). The major classes of the chondroitin family of GAGs are: chondroitin; chondroitin-4-sulfate (CS-A); dermatan sulfate (CS-B or DS), and chondroitin-6-sulfate (CS-C).
Description
Chondroitin Sulfate Structure, Role and Pharmacological Activity-Advances in Pharmacology, N. Volpi Ed., Elsevier, Chapter 9
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
CS Lyases: Structure, Activity and Applications in Analysis and the Treatment of Diseases, R.J. Linhardt, F.Y. Avci, T. Toida, Y.S. Kim, M. Cygler, Chondroitin Sulfate Structure, Role and Pharmacological Activity-Advances in Pharmacology, N. Volpi Ed., Elsevier, Chapter 9, 2006.
Publisher
Elsevier
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
10543589