Analysis of Glycosaminoglycan-Derived Oligosaccharides Using Fast Atom Bombardment Mass Spectrometry

Linhardt, Robert J.
Wang, Hui M.
Loganathan, Duraikkannu
Lamb, Diane J.
Mallis, Larry M.
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Analysis of Glycosaminoglycan-Derived Oligosaccharides Using Fast Atom Bombardment Mass Spectrometry, R.J. Linhardt, H.M. Wang, D. Loganathan, D. Lamb, L.M. Mallis, Carbohydrate Research, 225, 137-145 (1992).
Glycosaminoglycans (GAGS) are sulfated, linear polysaccharides found in mammalian tissues’, that play an important role in cell-cell interaction2 and demonstrate a wide variety of other important biological activities3. Polysaccharide lyases4.s can break down these GAGS into smaller oligosaccharides that exist in an ionized form and are usually isolated as sodium salts for structure determination.
Carbohydrate Research, 225, 137-145
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The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
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Rensselaer Polytechnic Institute, Troy, NY
Carbohydrate Research