Mechanics- and morphology-mimicking microchannel models of tumor microenvironments
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Authors
Kulwatno, Jonathan
Issue Date
2020-05
Type
Electronic thesis
Thesis
Thesis
Language
ENG
Keywords
Biomedical engineering
Alternative Title
Abstract
In this thesis, we took into consideration the structure of tubular tissues by considering them cylinders within a matrix, molding microchannels within materials to simulate the structure of these tissues. We then highlighted the importance of tubular tissue geometry in two ways: 1) we studied the influence of a vessel-like constraint on tumor emboli growth and morphology, demonstrating how the mechanical interplay between the emboli and vessel-like geometry can direct its growth and morphology and 2) we developed an organotypic mammary duct model that can recapitulate key features of breast cancer progression that is currently absent from literature.
Description
May 2020
School of Engineering
School of Engineering
Full Citation
Publisher
Rensselaer Polytechnic Institute, Troy, NY