A model and analysis for the onset and progression of Parkinson's disease

Authors
Caiola, Michael
ORCID
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Other Contributors
Holmes, Mark H.
Kovacic, Gregor
Kramer, Peter Roland, 1971-
Ligon, Lee
Issue Date
2016-08
Keywords
Mathematical sciences
Degree
PhD
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
Full Citation
Abstract
With this, the model is extended to include the entire cortico-basal ganglia-thalamo-cortical loop. This Full Model, is able to adequately account for the firing rates of six nuclei populations, using the same framework developed for the three population model. Additionally, these firing rates are shown to be consistent with the experimental firing rate data and tests done on individual basal ganglia connections. Again, using the tractability of the model it is shown how parameter-regions of stability can be found between four key connections. Mapping the progression of PD through these stability regions, insight can be gained on the order in which the disease takes root.
Description
August 2016
School of Science
Department
Dept. of Mathematical Sciences
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
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