A model and analysis for the onset and progression of Parkinson's disease
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Authors
Caiola, Michael
Issue Date
2016-08
Type
Electronic thesis
Thesis
Thesis
Language
ENG
Keywords
Mathematical sciences
Alternative Title
Abstract
With this, the model is extended to include the entire cortico-basal ganglia-thalamo-cortical loop. This Full Model, is able to adequately account for the firing rates of six nuclei populations, using the same framework developed for the three population model. Additionally, these firing rates are shown to be consistent with the experimental firing rate data and tests done on individual basal ganglia connections. Again, using the tractability of the model it is shown how parameter-regions of stability can be found between four key connections. Mapping the progression of PD through these stability regions, insight can be gained on the order in which the disease takes root.
Description
August 2016
School of Science
School of Science
Full Citation
Publisher
Rensselaer Polytechnic Institute, Troy, NY