A model and analysis for the onset and progression of Parkinson's disease

dc.contributorHolmes, Mark H.
dc.contributorKovacic, Gregor
dc.contributorKramer, Peter Roland, 1971-
dc.contributorLigon, Lee
dc.contributor.authorCaiola, Michael
dc.date.accessioned2021-11-03T08:39:49Z
dc.date.available2021-11-03T08:39:49Z
dc.date.created2016-09-27T14:11:35Z
dc.date.issued2016-08
dc.descriptionAugust 2016
dc.descriptionSchool of Science
dc.description.abstractWith this, the model is extended to include the entire cortico-basal ganglia-thalamo-cortical loop. This Full Model, is able to adequately account for the firing rates of six nuclei populations, using the same framework developed for the three population model. Additionally, these firing rates are shown to be consistent with the experimental firing rate data and tests done on individual basal ganglia connections. Again, using the tractability of the model it is shown how parameter-regions of stability can be found between four key connections. Mapping the progression of PD through these stability regions, insight can be gained on the order in which the disease takes root.
dc.description.degreePhD
dc.digitool.pid177526
dc.digitool.pid177527
dc.digitool.pid177528
dc.identifier.urihttps://hdl.handle.net/20.500.13015/1767
dc.language.isoENG
dc.publisherRensselaer Polytechnic Institute, Troy, NY
dc.relation.departmentDept. of Mathematical Sciences
dc.relation.ispartofRensselaer Theses and Dissertations Online Collection
dc.rights.holderThis electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
dc.rights.licenseRestricted to current Rensselaer faculty, staff and students. Access inquiries may be directed to the Rensselaer Libraries.
dc.subjectMathematical sciences
dc.titleA model and analysis for the onset and progression of Parkinson's disease
dc.typeElectronic thesis
dc.typeThesis
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