Manipulation and separation of objects at the microscale, in solution and at interfaces
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Authors
Pandey, Harsh
Issue Date
2015-08
Type
Electronic thesis
Thesis
Thesis
Language
ENG
Keywords
Chemical and biological engineering
Alternative Title
Abstract
Many separation techniques rely on different physical or chemical characteristics of the objects being separated. This includes separations based on size, total charge, or strength of interaction with a substrate. Recently there are many contexts in which it is important to manipulate or separate objects with much more subtle differences. For example, there has been significant interest in separating cells with different deformabilities because disease states can lead to changes in flexibility or stiffness, as observed in the red blood cells in sickle cell anemia. Proteins are another example in which manipulating molecules based on their flexibility or deformability (e.g. due to unfolding or di-sulfide bonds) is currently challenging. Further, genomic-length DNA separation and manipulation has direct applications in the development of novel DNA mapping and sequencing devices.
Description
August 2015
School of Engineering
School of Engineering
Full Citation
Publisher
Rensselaer Polytechnic Institute, Troy, NY