Targeted delivery of phycocyanin for prevention of colon cancer using electrospun fibers

Authors
Wen, Peng
Hu, Teng Gen
Wen, Yan
Linhardt, Robert J.
Zong, Min Hua
Zou, Yu Xiao
Wu, Hong
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
2019-04-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Targeted delivery of phycocyanin for prevention of colon cancer using electrospun fibers, P. Wen, T.-G. Hu, Y. Wen, R. J. Linhardt, M.-H. Zong, Y.-X. Zou, H. Wu, Food & Function, 10, 1816–1825, 2019.
Abstract
Phycocyanin (PC), a water-soluble biliprotein, exhibits potent anti-colon cancer properties. However, its application in functional foods is limited by the poor stability and low bioavailability of PC. In this study, we successfully encapsulated PC by coaxial electrospinning. The colon targeted release of PC was achieved with retention of the antioxidant activity of PC. The PC-loaded electrospun fiber mat (EFM) obtained inhibited HCT116 cell growth in a dose-dependent and time-dependent manner. In particular, the PC-loaded EFM exerted its anti-cancer activity by blocking the cell cycle at the G0/G1 phase and inducing cell apoptosis involving the decrease of Bcl-2/Bax, activation of caspase 3 and release of cytochrome c. This study suggests that co-axial electrospinning is an efficient and effective way to deliver PC and improve its bioavailability; thus, it represents a promising approach for encapsulating functional ingredients for colon cancer prevention.
Description
Food & Function, 10, 1816–1825
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Food and Function
https://harc.rpi.edu/
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