Targeted delivery of phycocyanin for prevention of colon cancer using electrospun fibers

Wen, Peng
Hu, Teng Gen
Wen, Yan
Linhardt, Robert J.
Zong, Min Hua
Zou, Yu Xiao
Wu, Hong
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Targeted delivery of phycocyanin for prevention of colon cancer using electrospun fibers, P. Wen, T.-G. Hu, Y. Wen, R. J. Linhardt, M.-H. Zong, Y.-X. Zou, H. Wu, Food & Function, 10, 1816–1825, 2019.
Phycocyanin (PC), a water-soluble biliprotein, exhibits potent anti-colon cancer properties. However, its application in functional foods is limited by the poor stability and low bioavailability of PC. In this study, we successfully encapsulated PC by coaxial electrospinning. The colon targeted release of PC was achieved with retention of the antioxidant activity of PC. The PC-loaded electrospun fiber mat (EFM) obtained inhibited HCT116 cell growth in a dose-dependent and time-dependent manner. In particular, the PC-loaded EFM exerted its anti-cancer activity by blocking the cell cycle at the G0/G1 phase and inducing cell apoptosis involving the decrease of Bcl-2/Bax, activation of caspase 3 and release of cytochrome c. This study suggests that co-axial electrospinning is an efficient and effective way to deliver PC and improve its bioavailability; thus, it represents a promising approach for encapsulating functional ingredients for colon cancer prevention.
Food & Function, 10, 1816–1825
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The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Food and Function