Unique cell surface mannan of yeast pathogen Candida auris with selective binding to IgG
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Authors
Yan, Lufeng
Xia, Ke
Yu, Yanlei
Miliakos, Anna
Chaturvedi, Sudha
Zhang, Fuming
Chen, Shiguo
Chaturvedi, Vishnu
Linhardt, Robert J.
Issue Date
2020-05-08
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
The emerging, multidrug-resistant yeast pathogen Candida auris is responsible for healthcare-associated outbreaks across the globe with high mortality. The rapid spread of C. auris is linked to its successful colonization of human skin, followed by bloodstream infections. We compared glycomics and proteomics of C. auris to closely and distantly related human pathogenic yeasts, C. haemulonii and C. albicans, with the aim to understand the role of cell surface molecules in skin colonization and immune system interactions. Candida auris mannan is distinct from other pathogenic Candida species, as it is highly enriched in β-1,2-linkages. The experimental data showed that C. auris surface mannan β-1,2-linkages were important for the interactions with the immune protein IgG, found in blood and in sweat glands, and with the mannose binding lectin, found in the blood. Candida auris mannan binding to IgG was from 12- to 20-fold stronger than mannan from the more common pathogen C. albicans. The findings suggest unique C. auris mannan could be crucial for the biology and pathogenesis of this emerging pathogen.
Description
ACS Infectious Diseases, 6, 1018−1031
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Unique cell surface mannan of yeast pathogen Candida auris with selective binding to IgG, L. Yan, K. Xia, Y. Yu, A. Miliakos, S. Chaturvedi, F. Zhang, Shiguo Chen,; V. Chaturvedi,; R. J. Linhardt, ACS Infectious Diseases, 6, 1018−1031, 2020.
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ISSN
23738227