Enzymatic polymerization of poly(glycerol-1,8-octanediol-sebacate): versatile PGS analogs that form mono-component biodegradable fiber scaffolds
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Authors
Lang, K.
Bhattacharya, S.
Ning, Z.
Sánchez-Leija, R.J.
Bramson, M.T.K.
Centore, R.
Corr, D.T.
Linhardt, Robert J.
Gross, R.A.
Issue Date
2020
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
A family of poly(glycerol sebacate) (PGS) analogues were synthesized by Candida antarctica lipase B (CALB) catalysis to tailor biomaterial properties. Different fractions of glycerol (G) units in PGS were replaced by 1,8-octanediol (O) units. Poly(glycerol-1,8-octanediol-sebacate), PGOS, synthesized by CALB catalysis with a 1:3 molar ratio of G to O units has Mn and Mw values of 9500 and 92,000, respectively. PGS undergoes fiber fusion during electrospinning, and cross-linked PGS rapidly resorbs when implanted. By decreasing the molar ratio of glycerol-to-octanediol from 1:1 to 1:4, the peak melting temperature (Tm) increased from 27 to 47 °C. PGOS with 1:3 G to O units was electrospun into nanofibers without the need for a second component. The copolymer is semicrystalline and, when cross-linked, undergoes slow in vitro mass loss (3.5 ± 1.0% in 31 days) at pH 7.4 and 37 °C. Furthermore, PGOS cross-linked films have an elastic modulus of 106.1 ± 18.6 MPa, which is more than 100 times that of cross-linked PGS. New PGOS polymers showed tunable molecular weights, better thermal properties, and excellent electrospinnability. This work expanded PGS analogues’ function, making these suitable biodegradable polymers for various biomedical applications.
Description
Biomacromolecules, 21, 3197-3206
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Enzymatic polymerization of poly(glycerol-1,8-octanediol-sebacate): versatile PGS analogs that form mono-component biodegradable fiber scaffolds, K. Lang, S. Bhattacharya, Z. Ning, R. J. Sánchez-Leija, M.T. K. Bramson, R. Centore, D. T. Corr, R. J. Linhardt, R.A. Gross, Biomacromolecules, 21, 3197-3206, 2020.