Preparation and Biological Activity of N-Sulfated Chondroitin and Dermatan Sulfate Derivatives

Authors
Nadkarni, V.D.
Toida, T.
VanGorp, C.L.
Schubert, R.L.
Weiler, J.M.
Hansen, K.P.
Caldwell, E.E.O.
Linhardt, Robert J.
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
1996
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Preparation and Biological Activity of N-Sulfated Chondroitin and Dermatan Sulfate Derivatives, V. D. Nadkarni, T. Toida, C.L. VanGorp, R.L. Schubert, J.M. Weiler, K.P. Hansen, E. E. O. Caldwell, R.J. Linhardt, Carbohydrate Research, 290, 87-96, 1996.
Abstract
Chondroitin and dermatan sulfates are families of structurally complex, sulfated, linear polysaccharides called glycosaminoglycans (GAGs) with alternating uronic acid and N-acetylated D-galactosamine residues [ 1] (Scheme 1). Chondroitin sulfate A (1A) consists of unsulfated D-glucuronic acid 1--* 3 linked to N-acetylated, 4-sulfated D-galactosamine, which in turn is attached to the next D-glucuronic acid residue by a 1 ~ 4 linkage. Chondroitin sulfate C (1B) has a 6-sulfate group on the N-acetylated D-galactosamine in place of the 4-sulfate found in chondroitin sulfate A. Dermatan sulfate, also called chondroitin sulfate B (2), is similar to chondroitin sulfate A but instead of D-glucuronic acid it consists mainly of L-iduronic acid. Both dermatan and chondroitin sulfates contain, on the average, one sulfate group per disaccharide unit.
Description
Carbohydrate Research, 290, 87-96
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
https://harc.rpi.edu/
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