In vivo mechanical modeling of multilayer biological soft tissue

Authors
Dargar, Saurabh
ORCID
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Other Contributors
De, Suvranu
Wang, Ge, 1957-
Zhang, Lucy T.
Vashishth, Deepak
Krüger, Uwe
Issue Date
2017-08
Keywords
Biomedical engineering
Degree
PhD
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
Full Citation
Abstract
Methods: To test tissue in vivo, a robotically manipulated compression head instrumented with a 30 MHz high-resolution ultrasound probe and load-cells was designed and developed. The layer-specific material properties of the tissue were iteratively optimized, as part of a finite element model, by minimizing an objective function that considers the difference between experimentally measured and computed axial and lateral displacements of the tissue as well as reaction forces at the indenter. The technique was successfully validated using tissue mimicking agar-based phantoms of varying material properties and geometries. Following validation, ex vivo studies were performed followed by in vivo studies on 10 porcine stomachs.
Description
August 2017
School of Engineering
Department
Dept. of Biomedical Engineering
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
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