In vivo mechanical modeling of multilayer biological soft tissue
Loading...
Authors
Dargar, Saurabh
Issue Date
2017-08
Type
Electronic thesis
Thesis
Thesis
Language
ENG
Keywords
Biomedical engineering
Alternative Title
Abstract
Methods: To test tissue in vivo, a robotically manipulated compression head instrumented with a 30 MHz high-resolution ultrasound probe and load-cells was designed and developed. The layer-specific material properties of the tissue were iteratively optimized, as part of a finite element model, by minimizing an objective function that considers the difference between experimentally measured and computed axial and lateral displacements of the tissue as well as reaction forces at the indenter. The technique was successfully validated using tissue mimicking agar-based phantoms of varying material properties and geometries. Following validation, ex vivo studies were performed followed by in vivo studies on 10 porcine stomachs.
Description
August 2017
School of Engineering
School of Engineering
Full Citation
Publisher
Rensselaer Polytechnic Institute, Troy, NY