Biodegradable and Bioactive Core-Shell Fibers for Tissue Engineering
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Authors
Hou, Lijuan
Zhang, Xing
Mikael, Paiyz E.
Lin, Lei
Dong, Wenjun
Zheng, Yingying
Simmons, Trevor John
Zhang, Fuming
Linhardt, Robert J.
Issue Date
2017-10-31
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Poly(glycerol sebacate) (PGS) has increasingly become a desirable biomaterial due to its elastic mechanical properties, biodegradability, and biocompatibility. Here, we report microfibrous core–shell mats of polycaprolactone (PCL)–PGS prepared using wet–wet coaxial electrospinning. The anticoagulant heparin was immobilized onto the surface of these electrospun fiber mats, and they were evaluated for their chemical, mechanical, and biological properties. The core–shell structure of PCL–PGS provided tunable degradation and mechanical properties. The slowly degrading PCL provided structural integrity, and the fast degrading PGS component increased fiber elasticity. Young’s modulus of PCL–PGS ranged from 5.6 to 15.7 MPa. The ultimate tensile stress ranged from 2.0 to 2.9 MPa, and these fibers showed elongation from 290 to 900%. The addition of PGS and grafting of heparin improved the attachment and proliferation of human umbilical vein endothelial cells. Core–shell PCL–PGS fibers demonstrate improved performance as three-dimensional fibrous mats for potential tissue-engineering applications.
Description
ACS Omega, 2, 6321−6328
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Biodegradable and Bioactive Core-Shell Fibers for Tissue Engineering, L. Hou, X. Zhang, P.E. Mikael, L. Lin, W. Dong, Y. Zheng, T. J. Simmons, F. Zhang, R. J. Linhardt, ACS Omega, 2, 6321−6328, 2017.
Publisher
American Chemical Society (ACS)
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
24701343