Chemometric analysis of porcine, bovine and ovine heparins

Ouyang, Yilan
Han, Xiaorui
Yu, Yanlei
Chen, Jianle
Fu, Li
Zhang, Fuming
Linhardt, Robert J.
Fareed, Jawed
Hoppensteadt, Debra
Jeske, Walter
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Chemometric analysis of porcine, bovine and ovine heparins, Y. Ouyang, X. Han, Y. Yu, J. Chen, F. Zhang, R. J. Linhardt, J. Fareed, D. Hoppensteadt, W. Jeske, A. Kouta, Z. Zhang, K. Xia, Journal of Pharmaceutical and Biomedical Analysis, 164, 345–352, 2019.
Heparin is a polysaccharide anticoagulant drug isolated from animal tissues. There have been concerns on the safety and security of the heparin supply chain since 2007-8 when a contamination crisis led to its disruption. The current study applies a suite of modern analytical techniques to porcine, bovine and ovine intestinal mucosal heparins. These techniques include structural analysis by nuclear magnetic resonance spectrometry, disaccharide compositional analysis, bottom-up analysis of tetrasaccharides corresponding to heparin's antithrombin III binding site. Chemometric analysis was then applied to understand how these structural differences to predict the animal/tissue source of heparin and to help detect blending of heparins from various sources.
Journal of Pharmaceutical and Biomedical Analysis, 164, 345–352
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The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Journal of Pharmaceutical and Biomedical Analysis