Xylosyltransferase 2 deficiency and organ homeostasis
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Authors
Ferencz, Beatrix
Condac, Eduard
Poudel, Nabin
Munteanu, Maria Cristina
Sivasami, Pulavendran
Choudhury, Biswa
Naidu, Nandita Natasha
Zhang, Fuming
Breshears, Melanie
Linhardt, Robert J.
Issue Date
2020-12-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
In this paper we characterize the function of Xylosyltransferase 2 (XylT2) in different tissues to investigate the role XylT2 has in the proteoglycan (PG) biochemistry of multiple organs. The results show that in all organs examined there is a widespread and significant decrease in total XylT activity in Xylt2 knock out mice (Xylt2-/-). This decrease results in increased organ weight differences in lung, heart, and spleen. These findings, in addition to our previous findings of increased liver and kidney weight with loss of serum XylT activity, suggest systemic changes in organ function due to loss of XylT2 activity. The Xylt2-/- mice have splenomegaly due to enlargement of the red pulp area and enhanced pulmonary response to bacterial liposaccharide. Tissue glycosaminoglycan composition changes are also found. These results demonstrate a role of XylT2 activity in multiple organs and their PG content. Because the residual XylT activity in the Xylt2-/- is due to xylosyltransferase 1 (XylT1), these studies indicate that both XylT1 and XylT2 have important roles in PG biosynthesis and organ homeostasis.
Description
Glycoconjugate Journal, 37, 755-765
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Xylosyltransferase 2 deficiency and organ homeostasis, B. Ferencz, E. Condac, N. Poudel, M.C. Munteanu, P. Sivasami, B. Choudhury, N.N. Naidu, F. Zhang, M. Breshears, R.J. Linhardt, M.E. Hinsdale, Glycoconjugate Journal, 37, 755-765, 2020.
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Volume
Issue
PubMed ID
DOI
ISSN
15734986
2820080
2820080