Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone

Authors
Folkman, Judah
Langer, Robert
Linhardt, Robert J.
Haudenschild, Christian
Taylor, Stephanie
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
1983-01-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone, J. Folkman, R. Langer, R.J. Linhardt, C. Haudenschild, S. Taylor, Science, 221, 719-725 (1983).
Abstract
Heparin or a heparin fragment administered with cortisone inhibited angiogenesis, caused regression of large tumor masses, and prevented metastases. Oral administration of heparin resulted in the release of non-anticoagulant heparin fragments in the serum which, in the presence of cortisone, had similar anti-angiogenic and antitumor effects. Of all the heparin fragments tested, the most potent inhibition of angiogenesis in the presence of cortisone was provided by a hexasaccharide with a molecular weight of about 1600.
Description
C. Haudenschild, S. Taylor, Science, 221, 719-725
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Science
https://harc.rpi.edu/
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