A fucoidan from sea cucumber Pearsonothuria graeffei with well-repeated structure alleviated gut microbiota dysbiosis and metabolic syndromes in HFD-fed mice
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Authors
Li, S.
Li, J.
Mao, G.
Wu, T.
Hu, Y.
Ye, X.
Tian, D.
Linhardt, Robert J.
Chen, S.
Issue Date
2018
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
A high-fat diet (HFD) has been a major contributor to increasing morbidity caused by metabolic syndromes. Functional foods from natural sources are potential choices for addressing metabolic diseases because they provide many health benefits with a low level of adverse side effects. In our former reports, fucoidan from Pearsonothuria graeffei (fuc-Pg), a type of sulfated polysaccharides with a repeating structure, was shown to be a potential functional food ingredient. In this work, we investigated the effects of fuc-Pg on gut microbiota dysbiosis and metabolic syndromes caused by HFD. Our results indicated that fuc-Pg could reduce weight gains, alleviate hyperlipidemia, and protect the liver from steatosis in HFD-fed mice. Meanwhile, fuc-Pg decreases serum inflammatory cytokines and reduces macrophages infiltrating into adipose tissue. The gut microbiota dysbiosis caused by HFD was alleviated by administration of fuc-Pg, mainly working in the colon. Fuc-Pg increased abundances of Bacteroidetes and Actinobacteria while decreased Firmicutes and Proteobacteria. Our results indicated that fuc-Pg could be a functional food for gut microbiota dysbiosis and metabolic syndromes.
Description
Food & Function, 9, 5371-5380
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
A fucoidan from sea cucumber Pearsonothuria graeffei with well-repeated structure alleviated gut microbiota dysbiosis and metabolic syndromes in HFD-fed mice, S. Li, J. Li, G. Mao, T. Wu, Y. Hu, X. Ye, D. Tian, R. J. Linhardt, S. Chen, Food & Function, 9, 5371-5380, 2018.