Combinatorial Enzymatic Synthesis of Heparan Sulfate

Authors
Linhardt, Robert J.
Kim, Jin Hwan
ORCID
https://orcid.org/0000-0003-2219-5833
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Issue Date
2007-09-21
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Full Citation
Combinatorial Enzymatic Synthesis of Heparan Sulfate, J.-H. Kim, R. J. Linhardt, Chemistry & Biology, 14, 972-973, 2007.
Abstract
Escherichia coli K5 heparosan was enzymatically modified by Chen and colleagues to construct a library of heparan sulfate polysaccharides for evaluation, leading to the discovery that a 2-O-sulfoiduronic acid residue is not essential for antithrombin-mediated anticoagulant activity in larger oligosaccharide and polysaccharide structures.
Description
Chemistry & Biology, 14, 972-973
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Elsevier
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Chemistry and Biology
https://harc.rpi.edu/
Access
A full text version is available in DSpace@RPI
Open Access
Elsevier User License https://www.elsevier.com/about/policies/open-access-licenses/elsevier-user-license