Combinatorial Enzymatic Synthesis of Heparan Sulfate

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Authors
Linhardt, Robert J.
Kim, Jin Hwan
Issue Date
2007-09-21
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Abstract
Escherichia coli K5 heparosan was enzymatically modified by Chen and colleagues to construct a library of heparan sulfate polysaccharides for evaluation, leading to the discovery that a 2-O-sulfoiduronic acid residue is not essential for antithrombin-mediated anticoagulant activity in larger oligosaccharide and polysaccharide structures.
Description
Chemistry & Biology, 14, 972-973
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Full Citation
Combinatorial Enzymatic Synthesis of Heparan Sulfate, J.-H. Kim, R. J. Linhardt, Chemistry & Biology, 14, 972-973, 2007.
Publisher
Elsevier
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Volume
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DOI
ISSN
10745521
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